FIG. 16.

Use of the Comprehensive Laboratory Animal Monitoring System to perform continuous indirect calorimetry in mice. (A) Two independent metabolic cages that are connected to a computer for recording and data analyses; (B) VO₂ during a 24 hour time period showing the nocturnal (shaded area) increase in metabolism; (C) respiratory quotient (RQ) during the same period of time, depicting the nocturnal (shaded area) increase in RQ when animals are kept on a carbohydrate-enriched diet; (D) dramatic increase in VO₂ during 48 hours cold exposure (shaded area); (E) decreased VO₂ in hypothyroid mice that were kept on 0.1% MMI for 60 days; (F) RQ in the animals shown in (E). Courtesy of Drs. Antonio Bianco and Tatiana Fonseca.