Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1975 Nov;72(11):4622–4625. doi: 10.1073/pnas.72.11.4622

Presence of norepinephrine and related enzymes in isolated brain microvessels.

F M Lai, S Udenfriend, S Spector
PMCID: PMC388775  PMID: 678

Abstract

Norepinephrine and the enzymes involved in its synthesis and degradation were found to be associated with isolated brain microvessels. The significance of these results are discussed with respect to adrenergic innervation of the cerebral microvessels and thereby neural regulation of the cerebral microcirculation.

Full text

PDF
4622

Images in this article

4623Image
on p.4623
4623Image
on p.4623
4624Image
on p.4624

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen G. S., Henderson L. M., Chou S. N., French L. A. Cerebral arterial spasm. 1. In vitro contractile activity of vasoactive agents on canine basilar and middle cerebral arteries. J Neurosurg. 1974 Apr;40(4):433–441. doi: 10.3171/jns.1974.40.4.0433. [DOI] [PubMed] [Google Scholar]
  2. Bertler A., Falck B., Owman C., Rosengrenn E. The localization of monoaminergic blood-brain barrier mechanisms. Pharmacol Rev. 1966 Mar;18(1):369–385. [PubMed] [Google Scholar]
  3. Bevan J. A., Duckles S. P., Lee T. J. Histamine potentiation of nerve- and drug-induced responses of a rabbit cerebral artery. Circ Res. 1975 May;36(5):647–653. doi: 10.1161/01.res.36.5.647. [DOI] [PubMed] [Google Scholar]
  4. Brendel K., Meezan E., Carlson E. C. Isolated brain microvessels: a purified, metabolically active preparation from bovine cerebral cortex. Science. 1974 Sep 13;185(4155):953–955. doi: 10.1126/science.185.4155.953. [DOI] [PubMed] [Google Scholar]
  5. Cervos-Navarro J., Matakas F. Electron microscopic evidence for innervation of intracerebral arterioles in the cat. Neurology. 1974 Mar;24(3):282–286. doi: 10.1212/wnl.24.3.282. [DOI] [PubMed] [Google Scholar]
  6. Christenson J. G., Dairman W., Udenfriend S. Preparation and properties of a homogeneous aromatic L-amino acid decarboxylase from hog kidney. Arch Biochem Biophys. 1970 Nov;141(1):356–367. doi: 10.1016/0003-9861(70)90144-x. [DOI] [PubMed] [Google Scholar]
  7. Dahl E. The innervation of the cerebral arteries. J Anat. 1973 May;115(Pt 1):53–63. [PMC free article] [PubMed] [Google Scholar]
  8. Fraser R. A., Stein B. M., Barrett R. E., Pool J. L. Noradrenergic mediation of experimental cerebrovascular spasm. Stroke. 1970 Sep-Oct;1(5):356–362. doi: 10.1161/01.str.1.5.356. [DOI] [PubMed] [Google Scholar]
  9. Goridis C., Neff N. H. Monoamine oxidase: an approximation of turnover rates. J Neurochem. 1971 Sep;18(9):1673–1682. doi: 10.1111/j.1471-4159.1971.tb03740.x. [DOI] [PubMed] [Google Scholar]
  10. Hartman B. K., Udenfriend S. Immunofluorescent localization of dopamine beta-hydroxylase in tissues. Mol Pharmacol. 1970 Jan;6(1):85–94. [PubMed] [Google Scholar]
  11. Hartman B. K., Udenfriend S. The application of immunological techniques to the study of enzymes regulating catecholamine synthesis and degradation. Pharmacol Rev. 1972 Jun;24(2):311–330. [PubMed] [Google Scholar]
  12. Hartman B. K., Zide D., Udenfriend S. The use of dopamine -hydroxylase as a marker for the central noradrenergic nervous system in rat brain. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2722–2726. doi: 10.1073/pnas.69.9.2722. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kato T., Kuzuya H., Nagatsu T. A simple and sensitive assay for dopamine-beta-hydroxylase activity by dual-wavelength spectrophotometry. Biochem Med. 1974 Aug;10(4):320–328. doi: 10.1016/0006-2944(74)90035-0. [DOI] [PubMed] [Google Scholar]
  14. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  15. Lavyne M., Wurtman R. J., Moskowitz M., Zervas N. Brain catecholamines and blood flow. Life Sci. 1975 Feb 15;16(4):475–486. [PubMed] [Google Scholar]
  16. NAGATSU T., LEVITT M., UDENFRIEND S. A RAPID AND SIMPLE RADIOASSAY FOR TYROSINE HYDROXYLASE ACTIVITY. Anal Biochem. 1964 Sep;9:122–126. doi: 10.1016/0003-2697(64)90092-2. [DOI] [PubMed] [Google Scholar]
  17. Nielsen K. C., Owman C. Contractile response and amine receptor mechanisms in isolated middle cerebral artery of the cat. Brain Res. 1971 Mar 19;27(1):33–42. doi: 10.1016/0006-8993(71)90370-2. [DOI] [PubMed] [Google Scholar]
  18. Owman C., Edvinsson L., Nielsen K. C. Autonomic neuroreceptor mechanisms in brain vessels. Blood Vessels. 1974;11(1-2):2–31. doi: 10.1159/000157996. [DOI] [PubMed] [Google Scholar]
  19. Owman C., Rosengren E. Dopamine formation in brain capillaries--an enzymic blood-brain barrier mechanism. J Neurochem. 1967 May;14(5):547–550. doi: 10.1111/j.1471-4159.1967.tb09553.x. [DOI] [PubMed] [Google Scholar]
  20. Samarasinghe D. D. The innervation of the cerebral arteries in the rat: an electron microscope study. J Anat. 1965 Oct;99(Pt 4):815–828. [PMC free article] [PubMed] [Google Scholar]
  21. Schlumpf M., Lichtensteiger W., Langemann H., Waser P. G., Hefti F. A fluorometric micromethod for the simultaneous determination of serotonin, noradrenaline and dopamine in milligram amounts of brain tissue. Biochem Pharmacol. 1974 Sep 1;23(17):2437–2446. doi: 10.1016/0006-2952(74)90235-4. [DOI] [PubMed] [Google Scholar]
  22. Wahl M., Kuschinsky W., Bosse O., Olesen J., Lassen N. A., Ingvar D. H., Michaelis J., Thurau K. Effect of 1-norepinephrine on the diameter of pial arterioles and arteries in the cat. Circ Res. 1972 Aug;31(2):248–256. doi: 10.1161/01.res.31.2.248. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES