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. 1975 Nov;72(11):4645–4649. doi: 10.1073/pnas.72.11.4645

Induction of error-prone repair as a consequence of DNA ligase deficiency in Escherichia coli.

L S Morse, C Pauling
PMCID: PMC388780  PMID: 1105587

Abstract

DNA ligase deficiency is shown to induce generalized mutator activity in E. coli. This mutator activity is unaffected by 3 mug/ml of chloramphenicol but is abolished both in lig-recA double mutants and by incubation with 20 mug/ml of chloramphenicol. Dna ligase deficiency is also shown to reactivate ultraviolet light-irradiated phage lambda and T7 and to increase both spontaneous and ultraviolet light-induced mutagenesis in phage lambda, all of which are abolished in lig-recA strains. Interaction occurs between the molecular events of mutagenesis induced by ultraviolet irradiation and those induced by DNA ligase deficiency. These observations suggest a common pathway, coordinately expressed with the inducible repair mode, that is responsible for mutagenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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