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Effects of siKEAP1 on transcript, protein and activities of E2 metabolizing enzymes. (A) Effect of siKEAP1 on levels of estrogen metabolism enzyme transcripts. (B) Effect of siKEAP1 on protein levels of estrogen metabolism enzymes. Scr, scrambled; siKp, siKEAP1. (C) Effect of siKEAP1 on NQO1 activity. MCF-10A cells were treated with siKEAP1 as described in Figure 2. Values are mean ± SE of three independent experiments. *Differs from scrambled control, P < 0.05.
