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. 1975 Dec;72(12):4910–4913. doi: 10.1073/pnas.72.12.4910

Infectious viral DNA of murine leukemia virus.

D Smotkin, A M Gianni, S Rozenblatt, R A Weinberg
PMCID: PMC388842  PMID: 1061080

Abstract

A fraction of the unintegrated viral DNA that appears early after infection of mouse cells by Moloney leukemia virus is infectious. The infectivity could be deomonstrated by an XC plaque assay of the cells exposed to DNA co-precipitated with calcium phosphate. The number of plaques deriving from closed-circular, supercoiled DNA was proportional to the concentration of added DNA, indicating that a single DNA molecule of about 5.5 X 10(6) daltons carries all the viral information. Nonsupercoiled viral DNA is also infectious; these molecules appear to be largely double-stranded and 5 to 6 X 10(6) dalthons in mass.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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