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. 1975 Dec;72(12):4923–4927. doi: 10.1073/pnas.72.12.4923

Neuronal properties of hybrid neuroblastoma X sympathetic ganglion cells.

L A Greene, W Shain, A Chalazonitis, X Breakfield, J Minna, H G Coon, M Nirenberg
PMCID: PMC388845  PMID: 1745

Abstract

Clonal mouse neuroblastoma cells without tyrosine 3-monooxygenase [EC 1.14.16.2; tyrosine hydroxylase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating)] activity were fused with normal cells from embryonic mouse sympathetic ganglia. One of the 37 hybrid cell lines obtained possesses high tyrosine 3-monooxygenase activity and synthesizes dopamine. These cells also have excitable membranes and generate action potentials in response to electrical stimuli. Thus hybrid cells, generated by fusion of neuroblastoma cells with normal cells from the nervous system, can acquire neural properties not found with the parental neuroblastoma cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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