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. 1971 Feb;68(2):263–264. doi: 10.1073/pnas.68.2.263

Synthetic Derivatives of Polyethyleneimine with Enzyme-Like Catalytic Activity (Synzymes)

Irving M Klotz 1, Garfield P Royer 1,*, Ioannis S Scarpa 1
PMCID: PMC388912  PMID: 16591900

Abstract

A synthetic polymer has been prepared which contains dodecyl groups (to bind small substrate molecules) and methyleneimidazole side chains (as nucleophilic catalytic sites) linked to a polyethyleneimine framework. This macromolecule, with a high local concentration of binding and catalytic groups, catalyzes the hydrolysis of uncharged nitrophenyl esters in water at pH 7 with rates markedly greater than previously observed with any other synthetic substances under similar conditions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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