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. 1971 Feb;68(2):299–302. doi: 10.1073/pnas.68.2.299

Interferon and Transcription of Early Virus-Specific RNA in Cells Infected with Simian Virus 40

Michael N Oxman 1,2,3, Myron J Levin 1,2,3
PMCID: PMC388922  PMID: 5277073

Abstract

Treatment with interferon reduced the content of early virus-specific RNA, as well as the content of an early viral protein (T antigen), in monkey cells acutely infected with simian virus 40 (SV40). This unexpected finding suggests either that the action of interferon involves inhibition of the transcription of early SV40 messenger RNA, or that the SV40 genome contains a “proto-early” gene whose product is required for the transcription of the remaining early genes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderer F. A., Schlumberger H. D., Koch M. A., Frank H., Eggers H. J. Structure of simian virus 40. II. Symmetry and components of the virus particle. Virology. 1967 Jul;32(3):511–523. doi: 10.1016/0042-6822(67)90303-0. [DOI] [PubMed] [Google Scholar]
  2. BLACK P. H., ROWE W. P. VIRAL STUDIES OF SV40 TUMORIGENESIS IN HAMSTERS. J Natl Cancer Inst. 1964 Jan;32:253–265. [PubMed] [Google Scholar]
  3. Baron S., Buckler C. E., McCloskey R. V., Kirschstein R. L. Role of interferon during viremia. I. Production of circulating interferon. J Immunol. 1966 Jan;96(1):12–16. [PubMed] [Google Scholar]
  4. Baron S., Levy H. B. Interferon. Annu Rev Microbiol. 1966;20:291–318. doi: 10.1146/annurev.mi.20.100166.001451. [DOI] [PubMed] [Google Scholar]
  5. Black P. H. The oncogenic DNA viruses: a review of in vitro transformation studies. Annu Rev Microbiol. 1968;22:391–426. doi: 10.1146/annurev.mi.22.100168.002135. [DOI] [PubMed] [Google Scholar]
  6. Buckler C. E., Baron S. Antiviral action of mouse interferon in heterologous cells. J Bacteriol. 1966 Jan;91(1):231–235. doi: 10.1128/jb.91.1.231-235.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Carter W. A., Levy H. B. Ribosomes: effect of interferon on their interaction with rapidly labeled cellular and viral RNA's. Science. 1967 Mar 10;155(3767):1254–1257. doi: 10.1126/science.155.3767.1254. [DOI] [PubMed] [Google Scholar]
  8. Carter W. A., Levy H. B. The recognition of viral RNA by mammalian ribosomes. An effect of interferon. Biochim Biophys Acta. 1968 Feb 26;155(2):437–443. doi: 10.1016/0005-2787(68)90189-5. [DOI] [PubMed] [Google Scholar]
  9. Eckhart W. Transformation of animal cells by oncogenic DNA viruses. Physiol Rev. 1968 Jul;48(3):513–533. doi: 10.1152/physrev.1968.48.3.513. [DOI] [PubMed] [Google Scholar]
  10. Friedman R. M., Sonnabend J. A. Mechanism of action of interferon. Arch Intern Med. 1970 Jul;126(1):51–63. [PubMed] [Google Scholar]
  11. Gillespie D., Spiegelman S. A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane. J Mol Biol. 1965 Jul;12(3):829–842. doi: 10.1016/s0022-2836(65)80331-x. [DOI] [PubMed] [Google Scholar]
  12. HOPPS H. E., BERNHEIM B. C., NISALAK A., TJIO J. H., SMADEL J. E. BIOLOGIC CHARACTERISTICS OF A CONTINUOUS KIDNEY CELL LINE DERIVED FROM THE AFRICAN GREEN MONKEY. J Immunol. 1963 Sep;91:416–424. [PubMed] [Google Scholar]
  13. ISAACS A., LINDENMANN J. Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci. 1957 Sep 12;147(927):258–267. doi: 10.1098/rspb.1957.0048. [DOI] [PubMed] [Google Scholar]
  14. Joklik W. K., Merigan T. C. Concerning the mechanism of action of interferon. Proc Natl Acad Sci U S A. 1966 Aug;56(2):558–565. doi: 10.1073/pnas.56.2.558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Joklik W. K. The poxviruses. Annu Rev Microbiol. 1968;22:359–390. doi: 10.1146/annurev.mi.22.100168.002043. [DOI] [PubMed] [Google Scholar]
  16. Kates J. R., McAuslan B. R. Poxvirus DNA-dependent RNA polymerase. Proc Natl Acad Sci U S A. 1967 Jul;58(1):134–141. doi: 10.1073/pnas.58.1.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Koch M. A., Eggers H. J., Anderer F. A., Schlumberger H. D., Frank H. Structure of simian virus 40. I. Purification and physical characterization of the virus particle. Virology. 1967 Jul;32(3):503–510. doi: 10.1016/0042-6822(67)90302-9. [DOI] [PubMed] [Google Scholar]
  18. LEVY H. B. STUDIES ON THE MECHANISM OF INTERFERON ACTION. II. THE EFFECT OF INTERFERON ON SOME EARLY EVENTS IN MENGO VIRUS INFECTION IN L CELLS. Virology. 1964 Apr;22:575–579. doi: 10.1016/0042-6822(64)90079-0. [DOI] [PubMed] [Google Scholar]
  19. Levin M. J., Oxman M. N., Diamandopoulos G. T., Levine A. S., Henry P. H., Enders J. F. Virus-specific nucleic acids in SV40-exposed hamster embryo cell lines: correlation with S and T antigens. Proc Natl Acad Sci U S A. 1969 Feb;62(2):589–596. doi: 10.1073/pnas.62.2.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Levy H. B., Carter W. A. Molecular basis of the action of interferon. J Mol Biol. 1968 Feb 14;31(3):561–577. doi: 10.1016/0022-2836(68)90428-2. [DOI] [PubMed] [Google Scholar]
  21. Magee W. E., Levine S., Miller O. V., Hamilton R. D. Inhibition by interferon of the uncoating of vaccinia virus. Virology. 1968 Aug;35(4):505–511. doi: 10.1016/0042-6822(68)90280-8. [DOI] [PubMed] [Google Scholar]
  22. Marcus P. I., Salb J. M. Molecular basis of interferon action: inhibition of viral RNA translation. Virology. 1966 Nov;30(3):502–516. doi: 10.1016/0042-6822(66)90126-7. [DOI] [PubMed] [Google Scholar]
  23. NYGAARD A. P., HALL B. D. FORMATION AND PROPERTIES OF RNA-DNA COMPLEXES. J Mol Biol. 1964 Jul;9:125–142. doi: 10.1016/s0022-2836(64)80095-4. [DOI] [PubMed] [Google Scholar]
  24. OHNO S., NOZIMA T. INHIBITORY EFFECT OF INTERFERON ON THE INDUCTION OF THYMIDINE KINASE IN VACCINIA VIRUS-INFECTED CHICK EMBRYO FIBROBLASTS. Acta Virol. 1964 Sep;8:479–479. [PubMed] [Google Scholar]
  25. Ohno S., Nozima T. Mode of action of interferon on the early stage of vaccinia virus multiplication in chick embryo fibroblasts. Acta Virol. 1966 Jul;10(4):310–314. [PubMed] [Google Scholar]
  26. Oxman M. N., Baron S., Black P. H., Takemoto K. K., Habel K., Rowe W. P. The effect of interferon on SV-40 T antigen production in SV-40-transformed cells. Virology. 1967 May;32(1):122–127. doi: 10.1016/0042-6822(67)90260-7. [DOI] [PubMed] [Google Scholar]
  27. Oxman M. N., Black P. H. Inhibition of SV40 T antigen formation by interferon. Proc Natl Acad Sci U S A. 1966 May;55(5):1133–1140. doi: 10.1073/pnas.55.5.1133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. POPE J. H., ROWE W. P. DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE. J Exp Med. 1964 Aug 1;120:121–128. doi: 10.1084/jem.120.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Rose J. A., Reich P. R., Weissman S. M. RNA production in adenovirus-infected KB cells. Virology. 1965 Dec;27(4):571–579. doi: 10.1016/0042-6822(65)90183-2. [DOI] [PubMed] [Google Scholar]
  30. Strander H., Cantell K. Production of interferon by human leukocytes in vitro. Ann Med Exp Biol Fenn. 1966;44(2):265–273. [PubMed] [Google Scholar]
  31. Taylor J. Inhibition of interferon action by actinomycin. Biochem Biophys Res Commun. 1964;14:447–451. doi: 10.1016/0006-291x(64)90084-1. [DOI] [PubMed] [Google Scholar]
  32. Todaro G. J., Baron S. The role of interferon in the inhibition of SV40 transformation of mouse cell line 3T3. Proc Natl Acad Sci U S A. 1965 Sep;54(3):752–756. doi: 10.1073/pnas.54.3.752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Travers A. A. Bacteriophage sigma factor for RNA polymerase. Nature. 1969 Sep 13;223(5211):1107–1110. doi: 10.1038/2231107a0. [DOI] [PubMed] [Google Scholar]
  34. WAGNER R. R., LEVY A. H. Interferon as a chemical intermediary in viral interference. Ann N Y Acad Sci. 1960 Nov 21;88:1308–1318. doi: 10.1111/j.1749-6632.1960.tb20122.x. [DOI] [PubMed] [Google Scholar]
  35. Wagner R. R. VIRAL INTERFERENCE. SOME CONSIDERATIONS OF BASIC MECHANISMS AND THEIR POTENTIAL RELATIONSHIP TO HOST RESISTANCE. Bacteriol Rev. 1960 Mar;24(1):151–166. doi: 10.1128/br.24.1.151-166.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Wong K. T., Baron S., Ward T. G. Rubella virus: role of interferon during infection of African green monkey kidney tissue cultures. J Immunol. 1967 Dec;99(6):1140–1149. [PubMed] [Google Scholar]

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