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. 1971 Feb;68(2):367–371. doi: 10.1073/pnas.68.2.367

Regulation of Methionine Biosynthesis in Escherichia coli: Mapping of the metJ Locus and Properties of a metJ+/metJ- Diploid

Ching-Hsiang Su 1,2, Ronald C Greene 1,2
PMCID: PMC388939  PMID: 5277087

Abstract

MetJ- mutants of Escherichia coli have elevated nonrepressible levels of the enzymes of methionine biosynthesis and S-adenosylmethionine synthetase (ATP:L-methionine S-adenosyltransferase, EC 2.5.1.6). In E. coli, as in Salmonella typhimurium, the metJ locus is close to metB (95% cotransduction of metB and metJ markers), but in E. coli the order is reversed, with metJ mapping clockwise to metB. A stable merodiploid, heterozygous for metJ, is subject to repression by methionine. Thus, metJ functions via a diffusible product. MetJ could either be a regulatory locus or could code for an enzyme required for the synthesis of a methionine metabolite that functions in the control system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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