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. 1971 Feb;68(2):378–382. doi: 10.1073/pnas.68.2.378

Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide

Charlotte Friend 1,2, William Scher 1,2, J G Holland 1,2, Toru Sato 1,2
PMCID: PMC388942  PMID: 5277089

Abstract

Cells of a cloned line of murine virus-induced erythroleukemia were stimulated to differentiate along the erythroid pathway by dimethyl sulfoxide at concentrations that did not inhibit growth. A rise in the number of benzidine-positive normoblasts was accompanied by increased synthesis of heme and hemoglobin and a decrease in the malignancy of the cells. This action of dimethyl sulfoxide, which was reversible, may represent the derepression of leukemic cells to permit their maturation.

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Selected References

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