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. 2013 Jun 26;10(1):91–104. doi: 10.1007/s11306-013-0555-4

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© The Author(s) 2013

Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 4 — EZTopolome(CHS-MET); isotopolome-wide association study (IWAS) array showing heat map [percent changes to CHS treated control (100 %)] of flux responses associated with MET treatment in BxPC-3 and the mutant K-ras (MIA PaCa-2) PDAC cell lines. EZTopolome(CHS-MET) contains group averages from Table 1 as percent of CHS values in an identical, coherent matrix format [please note CHS 100 % values are omitted for EZTopolome(CHS-MET)]. Visual system-wide association study (SWAS) evaluations show significant phenotypic differences after CHS treatment, as well as effects of MET for a rapid overview of Results. (@, P < 0.05 in comparison with CHS treated control (100 %); cholesterol ¹³C content 236 is not shown for comparison due to low values after external CHS treatment)