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. 1971 Apr;68(4):740–742. doi: 10.1073/pnas.68.4.740

Inducers of Interferon Inhibit the Mitotic Response of Liver Cells to Partial Hepatectomy

Rene I Jahiel 1,*, David Taylor 1, Norbert Rainford 1, Stephen E Hirschberg 1, Rayna Kroman 1
PMCID: PMC389032  PMID: 5279515

Abstract

Partially hepatectomized mice were injected with inducers of interferon, and the mitotic activity of liver cells was measured. The inducers were polyriboinosinic·polyribocytidylic acid, poly(I·C), Newcastle disease virus, and statolon. Each inhibited the mitosis of liver cells. Poly(I·C) was effective in doses as low as 1 μg per mouse. Polyriboinosinic acid, poly(I), had no inhibitory effect. These results extend the spectrum of action of inducers of interferon to inhibition of mitotic division of an aneoplastic, nonaneuploid mammalian cell.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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