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. 1971 Apr;68(4):773–776. doi: 10.1073/pnas.68.4.773

The Influence of Neighboring Base Pairs upon Base-Pair Substitution Mutation Rates

Robert E Koch 1
PMCID: PMC389040  PMID: 5279518

Abstract

The 2-aminopurine-induced transition, A·T → G·C, was studied at particular sites in bacteriophage T4 as a function of the nearby base-pair composition of the DNA. Changing a base pair changed the transition rate at the adjacent base pair up to 23-fold, and at the next base pair by a lesser amount. Destabilization was achieved by replacing an A·T base pair by a G·C base pair.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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