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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1971 May;68(5):920–924. doi: 10.1073/pnas.68.5.920

Antibody to the RNA-Dependent DNA Polymerase of Mammalian C-Type RNA Tumor Viruses

Stuart A Aaronson 1,2,3, Wade P Parks 1,2,3, Edward M Scolnick 1,2,3, George J Todaro 1,2,3
PMCID: PMC389081  PMID: 4325004

Abstract

Sera from rats bearing transplantable tumors induced by murine C-type tumor viruses contain an inhibitor of the activity of the viral RNA-dependent DNA polymerase. The inhibitor is shown to be an immunoglobulin (IgG) directed against the enzyme. Antiserum made in rabbits against partially purified murine leukemia virus polymerase also inhibits the polymerases of other mammalian C-type RNA-containing tumor viruses. Thus, the polymerases from different mammalian tumor viruses are antigenically related.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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