Abstract
If many gene loci are kept in a segregating state by natural selection, the equilibrium frequencies of the genotypes in the population may be a function of the amount of recombination among the genes. It is shown that if the equilibrium vector of gametic frequencies is a continuous function of the set of recombination frequencies among genes, then the mean fitness of the population at equilibrium is a maximum in the absence of recombination. Thus, in general, restriction of recombination increases fitness.
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- Franklin I., Lewontin R. C. Is the gene the unit of selection? Genetics. 1970 Aug;65(4):707–734. doi: 10.1093/genetics/65.4.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karlin S., Feldman M. W. Linkage and selection: new equilibrium properties of the two-locus symmetric viability model. Proc Natl Acad Sci U S A. 1969 Jan;62(1):70–74. doi: 10.1073/pnas.62.1.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LEWONTIN R. C. THE INTERACTION OF SELECTION AND LINKAGE. II. OPTIMUM MODELS. Genetics. 1964 Oct;50:757–782. doi: 10.1093/genetics/50.4.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lewontin R C. The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. Genetics. 1964 Jan;49(1):49–67. doi: 10.1093/genetics/49.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wright S. The Distribution of Gene Frequencies in Populations. Proc Natl Acad Sci U S A. 1937 Jun;23(6):307–320. doi: 10.1073/pnas.23.6.307. [DOI] [PMC free article] [PubMed] [Google Scholar]