Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1971 Jun;68(6):1095–1097. doi: 10.1073/pnas.68.6.1095

Induction of Translocations in Mature Drosophila Oocytes Over a Dose Range of 10-500 Roentgens of X-Rays

S Abrahamson 1,2, P Gullifor 1,2, E Sabol 1,2, J Voigtlander 1,2
PMCID: PMC389126  PMID: 5288360

Abstract

Data are presented that demonstrate that a dose of 10 R of x-rays to mature oocytes in Drosophila causes a significant increase, more than double the spontaneous frequency, of inherited translocations. The dose-frequency relationship appears to fit best a linear response between 10 and 50 R. From 50 to 500 R, the frequency of rearrangements increases at the conventional dose 3/2 relationship.

Keywords: stage-14 oocyte, radiation damage

Full text

PDF
1095

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abrahamson S, Herskowitz I H, Muller H J. Identification of Half-Translocations Produced by X-Rays in Detaching Attached-X Chromosomes of Drosophila Melanogaster. Genetics. 1956 May;41(3):410–419. doi: 10.1093/genetics/41.3.410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. KING R. C., RUBINSON A. C., SMITH R. F. Oogenesis in adult Drosophila melanogaster. Growth. 1956 Jun;20(2):121–157. [PubMed] [Google Scholar]
  3. Lindsley D L, Edington C W, Von Halle E S. Sex-Linked Recessive Lethals in Drosophila Whose Expression Is Suppressed by the Y Chromosome. Genetics. 1960 Dec;45(12):1649–1670. doi: 10.1093/genetics/45.12.1649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Parker D R, Hammond A E. The Production of Translocations in Drosophila Oocytes. Genetics. 1958 Jan;43(1):92–100. doi: 10.1093/genetics/43.1.92. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Parker D R, McCrone J. A Genetic Analysis of Some Rearrangements Induced in Oocytes of Drosophila. Genetics. 1958 Mar;43(2):172–186. doi: 10.1093/genetics/43.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. SHIOMI T., INAGAKI E., INAGAKI H., NAKAO Y. MUTATION RATES OF LOW DOSE LEVEL IN DROSOPHILA MELANOGASTER. J Radiat Res. 1963 Jun-Dec;4:105–110. doi: 10.1269/jrr.4.105. [DOI] [PubMed] [Google Scholar]
  7. Seeley B. A., Abrahamson S. The modification of x-ray-induced chromosome changes with anoxia in different oocyte stages of Drosophila melanogaster. Mutat Res. 1969 Mar-Apr;7(2):225–230. doi: 10.1016/0027-5107(69)90034-7. [DOI] [PubMed] [Google Scholar]
  8. Spencer W. P., Stern C. Experiments to Test the Validity of the Linear R-Dose/Mutation Frequency Relation in Drosophila at Low Dosage. Genetics. 1948 Jan;33(1):43–74. doi: 10.1093/genetics/33.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. TRAUT H. THE LINEAR DOSE-DEPENDENCE OF RADIATION-INDUCED TRANSLOCATION FREQUENCY IN DROSOPHILA MELANOGASTER AT RELATIVELY LOW X-RADIATION DOSES. Int J Radiat Biol Relat Stud Phys Chem Med. 1963 Oct;7:401–403. doi: 10.1080/09553006314551341. [DOI] [PubMed] [Google Scholar]
  10. Traut H. X-ray induction of autosomal translocations in mature oocytes of Drosophila melanogaster. Nature. 1967 May 13;214(5089):718–719. doi: 10.1038/214718a0. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES