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. 1971 Jun;68(6):1098–1101. doi: 10.1073/pnas.68.6.1098

In Vitro Transformation of Rodent Cells by K-Region Derivatives of Polycyclic Hydrocarbons

Philip L Grover 1,2, Peter Sims 1,2, Eliezer Huberman 1,2, Hans Marquardt 1,2, Toshio Kuroki 1,2, Charles Heidelberger 1,2,*
PMCID: PMC389127  PMID: 4108174

Abstract

The K-region epoxides and cis-dihydrodiols derived from benz(a)anthracene and from dibenz(a,h)-anthracene have been found to be more active in the production of malignant transformation in hamster embryo cells than the hydrocarbons or the corresponding K-region phenols. The K-region epoxides derived from benz(a)-anthracene and from 3-methylcholanthrene were also active in transforming a clone of ventral prostate cells from the C3H mouse that was not readily transformed by the parent hydrocarbons. The phenols were the most toxic compounds tested but did not transform cells; this confirms that toxicity and transformation are not directly related events. The results obtained support the view that metabolism of polycyclic hydrocarbons precedes toxicity and transformation in rodent cells in culture.

Keywords: tissue culture, epoxides, carcinogens, diols, phenols

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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