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. 1971 Jun;68(6):1195–1198. doi: 10.1073/pnas.68.6.1195

Conformation of Cyclolinopeptide A Observed by Circular Dichroism

Fred Naider 1, Ettore Benedetti 1, Murray Goodman 1
PMCID: PMC389152  PMID: 16591927

Abstract

A stereochemical investigation, by circular dichroism, of a synthetic nonapeptide (cyclolinopeptide A) in several organic and organic-sulfuric acid solvents is presented. From this examination, and results found for a conformationally rigid model compound, 1,7,7-trimethyl-3-azabicyclo [2.2.1] heptan-2-one(camphorolactam), it is concluded that cyclolinopeptide A may exist in several conformations in solution. None of these conformations is believed to be stabilized by intramolecular hydrogen bonds. Some details on an x-ray analysis of the cyclic nonapeptide are also presented.

Keywords: model compound, x-ray crystallography, organic solvents

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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