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. 1971 Jun;68(6):1208–1211. doi: 10.1073/pnas.68.6.1208

Analysis of the Events Leading to SV40-Induced Chromosome Replication and Mitosis in Primary Mouse Kidney Cell Cultures

Evelyne May 1,2,*, Pierre May 1,2, Roger Weil 1,2
PMCID: PMC389155  PMID: 4331083

Abstract

Abortive infection with simian virus 40 in confluent, “contact-inhibited”, mouse kidney cell cultures was studied. The sequential events, in individual cells, are tentatively represented by the simplified scheme: (a) transcription of early virus-specific (messenger) RNA; (b) appearance of T-antigen; (c) [psychrosensitive event(s)]; (d) chromosome replication; (e) normal or abnormal mitosis. No evidence for the replication of viral progeny DNA was obtained. The sequence of the events (a)-(d) is analogous to that observed in contact-inhibited mouse kidney tissue culture cells during lytic infection with polyoma virus.

Keywords: induced chromosome replication, mitosis, T-antigen, autoradiography

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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