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. 1971 Jun;68(6):1341–1345. doi: 10.1073/pnas.68.6.1341

Structural Basis of the A14 and A15 Allotypic Specificities in Rabbit Immunoglobulin G

E Appella 1,2, A Chersi 1,2, R G Mage 1,2, S Dubiski 1,2
PMCID: PMC389185  PMID: 5288384

Abstract

The structural basis for the A14 and A15 allotypic specificities of rabbit immunoglobulin G was investigated with Fe fragments prepared from homozygous rabbits. The presence of threonine in the Cγ2 region (position 309: Eu numbering) correlates with the A14 allotype; the presence of alanine at this same position correlates with the A15. Now that the sequence of the Cγ2 region of rabbit IgG has been completely elucidated, a high degree of homology of the constant region domains of rabbit and human γ chains is apparent (about 60-80%).

Keywords: column chromatography, protein sequencing, Fe, tryptic peptides, γ chains

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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