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. 1971 Jun;68(6):1369–1371. doi: 10.1073/pnas.68.6.1369

RNA-Dependent RNA Polymerase Activity in Influenza Virions

Edward Penhoet *,†,†, Henry Miller *, Michael Doyle *, Stanley Blatti
PMCID: PMC389191  PMID: 5288388

Abstract

An RNA-dependent RNA polymerase activity has been detected in purified preparations of influenza virus. In contrast to the replicase activity induced in influenza-infected cells, the virion-associated enzyme has an absolute requirement for Mn++. Most of the RNA synthesized in vitro is complementary to virion RNA.

Keywords: eggs, cell culture, Mn++ requirement, (NH4)2SO4 stimulation

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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