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. 1971 Jul;68(7):1441–1443. doi: 10.1073/pnas.68.7.1441

Effect of Rifampicin and Two of Its Derivatives on Cells Infected With Moloney Sarcoma Virus

Melvin Calvin 1, Urs R Joss 1, Adeline J Hackett 1, Robert B Owens 1
PMCID: PMC389213  PMID: 4327002

Abstract

It is shown that rifampicin, and especially the related antibiotic 2′,6′-dimethyl-N(4′)-benzyl-N(4′)- [desmethyl]rifampicin (DMB-rifampicin) can inhibit focus formation by Moloney sarcoma virus on BALB/3T3 tissue cultures. At 10 μg/ml DMB-rifampicin totally inhibits focus formation while reducing virus replication by at least a factor of fifty and cell proliferation by only a factor of three. These observations, taken together with those of others, suggest a role for an RNA-dependent DNA polymerase and the gene for its synthesis both in normal cell processes and in the transformation process.

Keywords: rifazine; 2′,6′-dimethyl-N(4′)-benzyl-N(4′)- [desmethyl]rifampicin

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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