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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1971 Jul;68(7):1547–1551. doi: 10.1073/pnas.68.7.1547

Interchain and Intrachain Disulfide Bridges of a Human Immunoglobulin M: Detection of a Unique Fragment

B Frangione 1, F Prelli 1, C Mihaesco 1,*, E C Franklin 1
PMCID: PMC389237  PMID: 4997757

Abstract

Studies of the amino acid sequences around half-cystine residues in an immunoglobulin M have revealed an unexpectedly high number. At least 14 different sequences were found in the μ chain (VHIII subclass). Four of these were involved in interchain disulfide bridges and at least 10 in intrachain bridges. Five came from the κ chain (κIII subclass, Inv b). Several others, although having a high degree of homology, were not identical with those of either the μ or κ chains. These results support the concept of an additional fragment in γM molecules, although its function and localization remain to be determined.

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Selected References

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