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. 1971 Jul;68(7):1598–1602. doi: 10.1073/pnas.68.7.1598

Selective Induction by Nerve Growth Factor of Tyrosine Hydroxylase and Dopamine-β-Hydroxylase in the Rat Superior Cervical Ganglia

H Thoenen *, P U Angeletti †, R Levi-Montalcini †, R Kettler *
PMCID: PMC389249  PMID: 5283951

Abstract

Treatment of newborn rats with 10 μg/g of nerve growth factor for 10 days enhanced not only the growth but also the differentiation of neuroblasts in superior cervical ganglia. These morphological changes were accompanied by selective induction of tyrosine hydroxylase and dopamine β-hydroxylase (EC 1.14.2.1), whereas the total and specific activities of other enzymes involved in biosynthesis or metabolic degradation of norepinephrine rose only in proportion to the increase in volume of the sympathetic ganglia. There are remarkable similarities between this effect of nerve growth factor and the induction of trans-synaptic enzymes by increased activity of the sympathetic nervous system.

Keywords: dopa decarboxylase, monoamine oxidase

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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