Abstract
In suspension cultures of mouse spleen cells, the addition of small amounts (1-100 ng) of a heterologous antigen to which the donor mice had been primed significantly increased the number of anti-sheep erythrocyte plaques appearing after stimulation with sheep erythrocytes. A similar addition to identical cultures from unprimed donors produced a small depression in the number of such plaques.
Keywords: mouse spleen cells, sheep erythrocytes, tetanus toxoid
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Selected References
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- Braun W., Nakano M. Antibody formation: stimulation by polyadenylic and polycytidylic acids. Science. 1967 Aug 18;157(3790):819–821. doi: 10.1126/science.157.3790.819. [DOI] [PubMed] [Google Scholar]
- Chanmougan D., Schwartz R. S. Enhancement of antibody synthesis by 6-mercaptopurine. J Exp Med. 1966 Sep 1;124(3):363–378. doi: 10.1084/jem.124.3.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Claman H. N., Chaperon E. A., Triplett R. F. Immunocompetence of transferred thymus-marrow cell combinations. J Immunol. 1966 Dec;97(6):828–832. [PubMed] [Google Scholar]
- DIXON F. J., McCONAHEY P. J. Enhancement of antibody formation by whole body x-radiation. J Exp Med. 1963 May 1;117:833–848. doi: 10.1084/jem.117.5.833. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOERLEIN A. B. The influence of colostrum on antibody response in baby pigs. J Immunol. 1957 Feb;78(2):112–117. [PubMed] [Google Scholar]
- JOHNSON A. G., GAINES S., LANDY M. Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide. J Exp Med. 1956 Feb 1;103(2):225–246. doi: 10.1084/jem.103.2.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Katz D. H., Paul W. E., Goidl E. A., Benacerraf B. Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions. J Exp Med. 1971 Feb 1;133(2):169–186. doi: 10.1084/jem.133.2.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kim Y. B., Bradley S. G., Watson D. W. Ontogeny of the immune response. I. Development of immunoglobulins in germfree and conventional colostrum-deprived piglets. J Immunol. 1966 Jul;97(1):52–63. [PubMed] [Google Scholar]
- Leskowitz S. Is delayed sensitivity a preparation for antibody synthesis? J Immunol. 1968 Sep;101(3):528–533. [PubMed] [Google Scholar]
- Mishell R. I., Dutton R. W. Immunization of dissociated spleen cell cultures from normal mice. J Exp Med. 1967 Sep 1;126(3):423–442. doi: 10.1084/jem.126.3.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mitchell G. F., Miller J. F. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J Exp Med. 1968 Oct 1;128(4):821–837. doi: 10.1084/jem.128.4.821. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mitchell G. F., Miller J. F. Immunological activity of thymus and thoracic-duct lymphocytes. Proc Natl Acad Sci U S A. 1968 Jan;59(1):296–303. doi: 10.1073/pnas.59.1.296. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mosier D. E. Cell interactions in the primary immune response in vitro: a requirement for specific cell clusters. J Exp Med. 1969 Feb 1;129(2):351–362. doi: 10.1084/jem.129.2.351. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OVARY Z., BENACERRAF B. IMMUNOLOGICAL SPECIFICITY OF THE SECONDARY RESPONSE WITH DINITROPHENYLATED PROTEINS. Proc Soc Exp Biol Med. 1963 Oct;114:72–76. doi: 10.3181/00379727-114-28589. [DOI] [PubMed] [Google Scholar]
- Rajewsky K., Schirrmacher V., Nase S., Jerne N. K. The requirement of more than one antigenic determinant for immunogenicity. J Exp Med. 1969 Jun 1;129(6):1131–1143. doi: 10.1084/jem.129.6.1131. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SEGRE D., KAEBERLE M. L. The immunologic behavior of baby pigs. II. Production of antibodies in newborn pigs. J Immunol. 1962 Dec;89:790–793. [PubMed] [Google Scholar]
- STAVITSKY A. B. Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. J Immunol. 1954 May;72(5):360–367. [PubMed] [Google Scholar]
- TERRES G., STONER R. D. Specificity of enhanced immunological sensitization of mice following injections of antigens and specific antisera. Proc Soc Exp Biol Med. 1962 Jan;109:88–91. doi: 10.3181/00379727-109-27112. [DOI] [PubMed] [Google Scholar]
- Talmage D. W., Pearlman D. S. The antibody response: a model based on antagonistic actions of antigen. J Theor Biol. 1963 Sep;5(2):321–339. doi: 10.1016/0022-5193(63)90067-5. [DOI] [PubMed] [Google Scholar]