Table 3.
Regions showing lower FA values associated with select risk factors. First 2 columns of results show regions revealing lower FA values between the Risk Cluster groups (FWER results along with post-hoc analyses are shown). For the fornix (FX), for example, RClus3 showed less FA than both RClus1 and RClus2. FWER results and correlations (ANCOVA) between FA values and the other risk factors are shown in the remaining columns. Age was adjusted for Risk Cluster groups, systolic blood pressure, A1C, and TC. In the last two columns, age covariates were not controlled, for comparison.
| FWER Multiple Comparison Tests, ANCOVAs, Post-Hocs for FA Regions | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Region | Cluster Groups | Systolic BP | A1C | TC | Age | |||||
| FWER | Post-Hoc | FWER | Corr | FWER | Corr | FWER | Corr | FWER | Corr | |
| FX | F=15.01 p<.0001 |
3<2 & 1 | F=20.01 p<.0001 |
r=−0.56 p<.0001 |
F=21.56 p<.0001 |
r=−0.57 p<.0001 |
F=67.98 p<.0001 |
r=−0.78 p<.0001 |
||
| GCC | F=10.74 p<.0002 |
3<2 & 1 | F=12.63 p<.0009 |
r=−0.47 p<.0009 |
F=21.78 p<.0001 |
r=−0.58 p<.0001 |
F=44.36 p<.0001 |
r=−0.71 p<.0001 |
||
| PTR-L | F=10.93 p<.0001 |
3<1 | F=16.96 p<.0002 |
r=−0.53 p<.0002 |
F=12.81 p<.0009 |
r=−0.48 p<.0009 |
F=43.20 p<.0001 |
r=−0.70 p<.0001 |
||
| PTR-R | F=11.53 p<.0001 |
3<1 | F=14.43 p<.0004 |
r=−0.50 p<.0004 |
F=14.16 p<.0005 |
r=−0.49 p<.0005 |
F=68.74 p<.0001 |
r=−0.78 p<.0001 |
||
| SS-R | F=8.49 p<.0008 |
3<1 | F=12.85 p<.0008 |
r=−0.48 p<.0008 |
F=18.20 p<.0001 |
r=−0.54 p<.0001 |
F=31.13 p<.0001 |
r=−0.64 p<.0001 |
||
| SS-L | F=7.91 p<.0001 |
3<2 & 1 | F=16.35 p<.0002 |
r=−0.52 p<.0002 |
F=18.53 p<.0001 |
r=−0.54 p<.0001 |
||||
| CGC-L | F=8.14 p<.007 |
r=−0.40 p<.007 |
||||||||
| CGC-R | F=8.36 p<.006 |
r=−0.40 p<.006 |
||||||||
| SLF-L | F=7.69 p<.008 |
r=−0.39 p<.008 |
||||||||
| SLF-R | F=7.72 p<.008 |
r=−0.39 p<.008 |
||||||||
| FX-ST-L | F=12.78 p<.0009 |
r=−0.47 p<.0009 |
||||||||
| FX-ST-R | F=10.42 p<.002 |
r=−0.44 p<.002 |
F=25.83 p<.0001 |
r=−0.61 p<.0001 |
||||||
| ACR-L | F=9.43 p<.0004 |
3<1 | F=33.69 p<.0001 |
r=−0.66 p<.0001 |
||||||
| ACR-R | F=10.48 p<.0002 |
3<1 | F=31.07 p<.0001 |
r=−0.64 p<.0001 |
||||||
| BCC | F=24.78 p<.0001 |
r=−0.60 p<.0001 |
||||||||
| SCR-R | F=20.71 p<.0001 |
r=−0.57 p<.0001 |
||||||||
| SCR-L | F=18.91 p<.0001 |
r=−0.55 p<.0001 |
||||||||
| SCC | F=8.5 p<.0008 |
3<1 | ||||||||
GCC=genu of the corpus callosum; PTR=posterior thalamic radiation (right and left); SS=sagittal stratum (right and left); CGC=cingulum/cingulate gyrus (right and left); SLF= superior longitudinal fasciculus (right and left); FX-ST=crus of the fornix and stria terminalis (right and left); ACR= anterior corona radiata (right and left); BCC=body of the corpus callosum; SCR=superior corona radiata (right and left); SCC= splenium of the corpus callosum.