Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1971 Aug;68(8):1862–1865. doi: 10.1073/pnas.68.8.1862

Divergence between Immunosuppression and Immunocompetence during Virus-Induced Leukemogenesis

Jan Cerny *,, Robert F McAlack *,, Walter S Ceglowski *, Herman Friedman *,
PMCID: PMC389309  PMID: 4942915

Abstract

Mice were infected with Friend leukemia virus and later immunized with either Vibrio cholerae vaccine or sheep erythrocytes. The primary antibody response to the bacteria (as judged by the number of plaque-forming cells) was slightly enhanced by the viral infection, whereas the response to sheep erythrocytes was inhibited. The difference appeared due to sensitization of mice to antigens crossreacting with those of sheep erythrocytes; no natural immunity to V. cholerae is detectable. However, the response of mice infected with Friend leukemia virus to a secondary challenge with the cholera bacteria was markedly inhibited. Even though the number of plaque-forming cells during the primary response was not reduced, accumulation of the cells in distinct splenic foci was suppressed. These results suggest that the effect of Friend leukemia virus on immunocompetent cells is selective. The immune response appears to be susceptible to leukemia virus-induced immunosuppression only when there has been a previous stimulation of immunocytes by antigen.

Keywords: mice, Friend leukemia virus, Vibrio cholerae, sheep erythrocytes

Full text

PDF
1862

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen J., Young I., Friedman H. Detection and localization of antibody-forming cells to a bacterial endotoxin by an immunobioautographic procedure. Proc Soc Exp Biol Med. 1969 Feb;130(2):615–620. doi: 10.3181/00379727-130-33620. [DOI] [PubMed] [Google Scholar]
  2. Ceglowski W. S., Friedman H. Immunosuppression by leukemia viruses. 3. Adoptive transfer of antibody-forming cells to Friend disease virus-infected mice. J Immunol. 1969 Sep;103(3):460–466. [PubMed] [Google Scholar]
  3. Ceglowski W. S., Friedman H. Immunosuppression by leukemia viruses. I. Effect of Friend disease virus on cellular and humoral hemolysin responses of mice to a primary immunization with sheep erythrocytes. J Immunol. 1968 Sep;101(3):594–604. [PubMed] [Google Scholar]
  4. Ceglowski W. S., Friedman H. Immunosuppression by leukemia viruses. II. Cytokinetics of appearance of hemolysin-forming cells in infected mice during the anamnestic response to sheep erythrocytes. J Immunol. 1969 Feb;102(2):338–346. [PubMed] [Google Scholar]
  5. Cerný J., Viklický V., Hraba T. Paralysing treatment with protein antigen in mice. II. Globulin-containing cells, haematopoietic stem cells and plaque-forming (anti-sRBC) cells in the spleen. Folia Biol (Praha) 1969;15(2):104–116. [PubMed] [Google Scholar]
  6. Hanna M. G., Jr, Walburg H. E., Jr, Tyndall R. L., Snodgrass M. J. Histoproliferative effect of Rauscher leukemia virus on lymphatic tissue. II. Antigen-stimulated germfree and conventional BALB-c mice. Proc Soc Exp Biol Med. 1970 Sep;134(4):1132–1141. doi: 10.3181/00379727-134-34959. [DOI] [PubMed] [Google Scholar]
  7. Hirano S., Friedman H. Effect of a murine leukaemia virus on "backgroud" antibody plaque-forming cells to sheep erythrocytes and E. coli antigen. Nature. 1969 Dec 27;224(5226):1316–1318. doi: 10.1038/2241316a0. [DOI] [PubMed] [Google Scholar]
  8. Iványi J., Cerný J. The significance of the dose of antien in immunity and tolerance. Curr Top Microbiol Immunol. 1969;49:114–150. doi: 10.1007/978-3-642-46166-8_3. [DOI] [PubMed] [Google Scholar]
  9. McAlack R. F., Cerny J., Allen J. L., Friedman H. Vibriolytic antibody-forming cells: a new application of the Pfeiffer phenomenon. Science. 1970 Apr 3;168(3927):141–142. doi: 10.1126/science.168.3927.141. [DOI] [PubMed] [Google Scholar]
  10. Notkins A. L., Mergenhagen S. E., Rizzo A. A., Scheele C., Waldmann T. A. Elevated gamma-globulin and increased antibody production in mice infected with lactic dehydrogenase virus. J Exp Med. 1966 Feb 1;123(2):347–364. doi: 10.1084/jem.123.2.347. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES