Table 3. Prevention of RSV replication by prophylactic mAb treatment in cotton rats.
Groups consisting of 5–6 cotton rats treated with mAb or PBS (control) 1 d prior to intranasal challenge with 2.25 x 105 pfu of RSV (Tracy) in 0.1 ml. Unless otherwise indicated, all animals received mAb intramuscularly. Viral titer was assessed 4 d post-challenge. IP = intraperitonal, SD = standard deviation. P-values were determined by ANOVA with a follow-up Dunnett’s pairwise comparison test.