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. 1971 Sep;68(9):2057–2061. doi: 10.1073/pnas.68.9.2057

Regulation of Protein Synthesis Initiation in HeLa Cells Deprived of Single Essential Amino Acids

Maurice H Vaughan Jr 1,*, Philip J Pawlowski 1,†, J Forchhammer 1,‡
PMCID: PMC389350  PMID: 5289364

Abstract

In HeLa cells deprived of valine, histidine, or methionine initiation of protein synthesis decreases rapidly and disaggregation of polyribosomes also occurs. The mechanism of inhibition does not seem to involve the supply of RNA in the cell, and thus it differs from the initiation of inhibition at elevated temperatures. Polyribosomes rapidly form again if the missing amino acid is restored, even in the presence of actinomycin D.

Keywords: valine, histidine, methionine, high-temperature inhibition

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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