Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1971 Sep;68(9):2112–2116. doi: 10.1073/pnas.68.9.2112

Clock Mutants of Drosophila melanogaster

Ronald J Konopka 1, Seymour Benzer 1
PMCID: PMC389363  PMID: 5002428

Abstract

Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed. One mutant is arrhythmic; another has a period of 19 hr; a third has a period of 28 hr. Both the eclosion rhythm of a population and the locomotor activity of individual flies are affected. All these mutations appear to involve the same functional gene on the X chromosome.

Keywords: eclosion, circadian, rhythms, X chromosome

Full text

PDF
2112

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHANCE B., ESTABROOK R. W., GHOSH A. DAMPED SINUSOIDAL OSCILLATIONS OF CYTOPLASMIC REDUCED PYRIDINE NUCLEOTIDE IN YEAST CELLS. Proc Natl Acad Sci U S A. 1964 Jun;51:1244–1251. doi: 10.1073/pnas.51.6.1244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Feldman J. F. Lengthening the period of a biological clock in Euglena by cycloheximide, an inhibitor of protein synthesis. Proc Natl Acad Sci U S A. 1967 Apr;57(4):1080–1087. doi: 10.1073/pnas.57.4.1080. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Frank K. D., Zimmerman W. F. Action spectra for phase shifts of a circadian rhythm in Drosophila. Science. 1969 Feb 14;163(3868):688–689. doi: 10.1126/science.163.3868.688. [DOI] [PubMed] [Google Scholar]
  4. KARAKASHIAN M. W., HASTINGS J. W. The inhibition of a biological clock by actinomycin D. Proc Natl Acad Sci U S A. 1962 Dec 15;48:2130–2137. doi: 10.1073/pnas.48.12.2130. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Karakashian M. W. The rhythm of mating in Paramecium aurelia, syngen 3. J Cell Physiol. 1968 Jun;71(3):197–209. doi: 10.1002/jcp.1040710303. [DOI] [PubMed] [Google Scholar]
  6. Pittendrigh C. S. Circadian systems. I. The driving oscillation and its assay in Drosophila pseudoobscura. Proc Natl Acad Sci U S A. 1967 Oct;58(4):1762–1767. doi: 10.1073/pnas.58.4.1762. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Pittendrigh C. S., Skopik S. D. Circadian systems. V. The driving oscillation and the temporal sequence of development. Proc Natl Acad Sci U S A. 1970 Mar;65(3):500–507. doi: 10.1073/pnas.65.3.500. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pye K., Chance B. Sustained sinusoidal oscillations of reduced pyridine nucleotide in a cell-free extract of Saccharomyces carlsbergensis. Proc Natl Acad Sci U S A. 1966 Apr;55(4):888–894. doi: 10.1073/pnas.55.4.888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Roberts S. K. "Clock" Controlled Activity Rhythms in the Fruit Fly. Science. 1956 Jul 27;124(3213):172–172. doi: 10.1126/science.124.3213.172. [DOI] [PubMed] [Google Scholar]
  10. Sargent M. L., Briggs W. R., Woodward D. O. Circadian nature of a rhythm expressed by an invertaseless strain of Neurospora crassa. Plant Physiol. 1966 Oct;41(8):1343–1349. doi: 10.1104/pp.41.8.1343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Vanden Driessche T. The role of the nucleus in the circadian rhythms of Acetabularia mediterranea. Biochim Biophys Acta. 1966 Nov 8;126(3):456–470. doi: 10.1016/0926-6585(66)90005-7. [DOI] [PubMed] [Google Scholar]
  12. Zimmerman W. F., Pittendrigh C. S., Pavlidis T. Temperature compensation of the circadian oscillation in drosophila pseudoobscura and its entrainment by temperature cycles. J Insect Physiol. 1968 May;14(5):669–684. doi: 10.1016/0022-1910(68)90226-6. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES