Figure 1. De novo mutations in persons with schizophrenia and unaffected siblings.

(A) All de novo point mutations in 189 persons. Observed numbers of events fit a Poisson distribution with m = 0.87 events per person. R² = 0.97 for goodness of fit of observed to expected values under Poisson assumption.

(B) De novo point mutations in 189 offspring by terciles of paternal age. Presence of at least one de novo point mutation is associated with older paternal age (X² = 13.96, p = 0.0009).

(C). Presence of at least one de novo putatively damaging mutation in schizophrenia probands and unaffected siblings. 45% (47/105) of the probands and 30% (25/84) of the unaffected siblings carried at least one damaging de novo mutation (X²=4.45, P=0.035).

(D) Genes harboring de novo damaging mutations in persons with schizophrenia. Colors represent types of mutations: blue are missense, red are nonsense, black are frameshift, green are splice, and orange are CNVs.