Table 1.
Patients Characteristics Stratified by Median Percent Mismatch Loss (PML)
| Parameter* | All Patients | “Low” Mismatch-loss |
“High” Mismatch-loss |
P |
|---|---|---|---|---|
| Subjects, n (%) | 45 | 23 (51%) | 22 (49%) | - |
| Admit PML, median(IQR) | 30.0% (7.6–65.3) | 8.1% (4.2–13.1) | 68.2% (52.1–100) | <0.0001 |
| Age (year), mean (±SD) | 72.4 (±17.1) | 68.9 (±18.8) | 76.1 (±14.5) | 0.15 |
| Gender (male), n (%) | 19 (42%) | 9 (40%) | 10 (45%) | 0.77 |
| Atrial fibrillation, n (%) | 18 (40%) | 10 (43%) | 8 (36%) | 0.76 |
| Hypertension, n (%) | 34 (75%) | 16 (70%) | 18 (81%) | 0.49 |
| Coronary artery disease, n (%) | 15 (33%) | 6 (26%) | 9 (40%) | 0.35 |
| Diabetes mellitus, n (%) | 3 (6%) | 1 (4%) | 2 (9%) | 0.61 |
| Admit NIHSS, median (IQR) | 14 (9–19) | 9 (5.25–13.75) | 17.5 (15–22) | <0.0001 |
| Laterality (right sided), n (%) | 29 (64%) | 16 (69%) | 13 (59%) | 0.54 |
| Admit DWI infarct-vol (ml), mean (±SD) | 30.9 (±38.8) | 13.1 (±25.9) | 49.6 (±41.7) | 0.0013 |
| DWI infarct-vol <100ml, n(%) | 40 (89%) | 22 (96%) | 18 (82%) | 0.15 |
| Admit DWI-ASPECT score, median (IQR) | 6 (4.75–7) | 7 (7–8) | 5 (3–6) | <0.0001 |
| Admit MTT vol (ml), mean (±SD) | 161.1 (±74.6) | 151.1 (±70.5) | 171.5 (±79.1) | 0.36 |
| Admit PIRI, median (IQR) | 3 (0.75–4) | 1 (0–1.75) | 4 (3–4) | <0.0001 |
| Admit PIRI >25%, n (%) | 26/45 (58%) | 6/23 (26%) | 20/22 (91%) | <0.0001 |
| Time to DWI (hr), mean (±SD) | 5.1 (±1.9) | 5.3 (±1.9) | 4.7 (±1.9) | 0.29 |
| Admit CTA-Collateral Score, median (IQR) | 3 (2–4) | 4 (3–5) | 2.5 (2–3) | 0.0023 |
| Treatment (IV-tPA and/or IA), n (%) | 21 (46%) | 8 (35%) | 13 (59%) | 0.14 |
| Final Infarct Volume (ml), mean (±SD) | 87.9 (±92.3) | 29.4 (±36.8) | 149.1 (±93.6) | <0.0001 |
PIRI= percent insular-ribbon infarct, NIHSS= NIH-stroke-scale score, DWI= diffusion weighted imaging, ASPECT= Alberta-stroke-program-early-CT score, MTT= mean-transit-time MRI perfusion maps, CTA= CT angiography, tPA= tissue-plasminogen-activator, IA= intra-arterial,
*
Median percent mismatch loss was 30%
†
Continuous, ordinal and discrete variables compared with unpaired t-test, Mann-Whitney U-test and Fisher's Exact test, respectively.