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. 1971 Oct;68(10):2391–2395. doi: 10.1073/pnas.68.10.2391

Helper Activity of Human Leukemic Tissue Extracts for Leukemia Virus Expression in Mice

Richard A Steeves 1,2, Audrey Fjelde 1,2, Edwin A Mirand 1,2
PMCID: PMC389429  PMID: 4332810

Abstract

Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1b gene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leukemia viruses of mice, cats, or chickens to substitute for the inhibited helper virus and increase the expression of the spleen focus-forming virus. The helper activity of extracts from human leukemic tissues shared several important properties with that associated with known leukemogenic viruses of animals.

Keywords: BALB, c mice, Fv-1b gene, Friend virus complex, spleen focus-forming virus

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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