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. 1971 Oct;68(10):2396–2400. doi: 10.1073/pnas.68.10.2396

Production of Albumin and Other Serum Proteins by Clonal Cultures of Normal Human Liver

M Edward Kaighn 1, Alfred M Prince 1
PMCID: PMC389430  PMID: 5002818

Abstract

Clonal cell strains have been isolated from normal human liver. These cells, while resembling fibroblasts morphologically, function as hepatocytes, as shown by their ability to synthesize and secrete an antigen identical to human serum albumin. Human diploid and aneuploid cell lines from nonliver sources do not exhibit this property. The spectrum of serum proteins synthesized varied from clone to clone and cell line to cell line.

Keywords: human embryonic cells, human hepatocytes, human liver cells, cytodifferentiation

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Selected References

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