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. 1971 Oct;68(10):2579–2583. doi: 10.1073/pnas.68.10.2579

Spin-Label Electron Spin Resonance Study of the Lipid-Containing Membrane of Influenza Virus

Frank R Landsberger *,§, John Lenard *, John Paxton †, Richard W Compans ‡
PMCID: PMC389472  PMID: 4332817

Abstract

The organization of the lipid-containing membrane of influenza virus has been studied by the use of three different lipid spin labels, and the results are compared with a parallel study on human erythrocyte ghosts. The lipid phase of the viral membrane is slightly more rigid than that of the erythrocyte ghosts. The data suggest that the viral lipid is arranged in a bilayer. The data suggest that the viral lipid is arranged in a bilayer. The glycoprotein spikes covering the viral membrane were specifically removed by proteases, and no alteration in the environment of any of the three spin labels was detected. This suggests that the spikes are not involved in determining the organization of the lipid bilayer.

Keywords: erythrocyte ghosts, stearate label, androstane label, membrane glycoproteins

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Selected References

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