Abstract
Late lethal mutants of Drosophila melanogaster, dying after the larval stage of development, were isolated. The homozygous mutant larvae were examined for abnormal imaginal disc morphology, and the discs were injected into normal larval hosts to test their capacities to differentiate into adult structures. In about half of the mutants analyzed, disc abnormalities were found. Included among the abnormalities were missing discs, small discs incapable of differentiating, morphologically normal discs with limited capacities for differentiation, and discs with homeotic transformations. In some mutants all discs were affected, and in others only certain discs. The most extreme abnormal phenotype is a class of “discless” mutants. The viability of these mutant larvae indicates that the discs are essential only for the development of an adult and not of a larva. The late lethals are therefore a major source of mutants for studying the genetic control of disc formation.
Keywords: genetic control, development
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Beadle G. W., Ephrussi B. The Differentiation of Eye Pigments in Drosophila as Studied by Transplantation. Genetics. 1936 May;21(3):225–247. doi: 10.1093/genetics/21.3.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carlson E. A., Sederoff R., Cogan M. Evidence favoring a frame shift mechanism for ICR-170 induced mutations in Drosophila melanogaster. Genetics. 1967 Feb;55(2):295–313. doi: 10.1093/genetics/55.2.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mandaron P. Développement in vitro des disques imaginaux de la drosophile. Aspects morphologiques et histologiques. Dev Biol. 1970 Jun;22(2):298–320. doi: 10.1016/0012-1606(70)90156-9. [DOI] [PubMed] [Google Scholar]
- Schneider I. Histology of larval eye-antennal disks and cephalic ganglia of Drosophila cultured in vitro. J Embryol Exp Morphol. 1966 Jun;15(3):271–279. [PubMed] [Google Scholar]