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. 1971 Nov;68(11):2623–2626. doi: 10.1073/pnas.68.11.2623

Amino Acid Sequence of the Light Chain from a Mouse Myeloma Protein with Anti-Hapten Activity: Evidence for a Third Type of Light Chain

Elizabeth P Schulenburg *, Ernest S Simms *, Richard G Lynch *, Ralph A Bradshaw *,*, Herman N Eisen *
PMCID: PMC389486  PMID: 5288236

Abstract

A tentative amino acid sequence has been determined for the light chain of a mouse A-myeloma (MOPC-315) protein with anti-2,4-dinitrophenyl activity. An unusual amino acid sequence in the carboxyl-terminal 104 residues suggests that the chain represents a new class of immunoglobulin light chain. The “variable” segment of this chain (amino-terminal 110 residues) differs at only eight positions from the corresponding segment of the lambda chain of a mouse M-myeloma (MOPC-104) protein with anti-dextran activity.

Keywords: anti-2,4-dinitrophenyl activity; carboxyl-terminal residues; N-terminal residues; κ and λ chains

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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