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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1971 Nov;68(11):2691–2693. doi: 10.1073/pnas.68.11.2691

Studies on Phosphorylation by Phosphoroguanidinates. The Mechanism of Action of Creatine: ATP Transphosphorylase (Creatine Kinase)

Paul Haake 1, Gary W Allen 1
PMCID: PMC389502  PMID: 5288244

Abstract

The solvolyses of phosphorocreatine (creatine phosphate) and models for phosphorocreatine have been investigated and the results are applied to the mechanism of action of creatine kinase (EC 2.7.3.2). A metaphosphate intermediate appears to be involved.

Keywords: solvolyses, creatinine, dimethylphosphoroguanidinate, methylbenzylphosphoroguanidinate, reaction kinetics

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CLARK V. M., TODD L., WARREN S. G. STUDIES ON PHOSPHORYLATION. XXV. METAL ION CATALYSED REACTIONS OF PHOSPHAGENS. Biochem Z. 1963;338:591–598. [PubMed] [Google Scholar]
  2. Mildvan A. S., Cohn M. Aspects of enzyme mechanisms studies by nuclear spin relazation induced by paramagnetic probes. Adv Enzymol Relat Areas Mol Biol. 1970;33:1–70. doi: 10.1002/9780470122785.ch1. [DOI] [PubMed] [Google Scholar]

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