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. 1971 Nov;68(11):2734–2738. doi: 10.1073/pnas.68.11.2734

Appearance of T-cell Markers in Bone Marrow Rosette-Forming Cells after Incubation with Thymosin, a Thymic Hormone

Jean-Francois Bach *, Mireille Dardenne *, Allan L Goldstein ‡, Arabinda Guha ‡, Abraham White ‡
PMCID: PMC389512  PMID: 4399414

Abstract

After incubation with thymosin, a thymic hormone, normal bone marrow rosette-forming cells acquire T-cell characteristics, including increased sensitivity to azathioprine, anti-lymphocyte serum, and anti-theta serum. This activity of thymosin provides a new sensitive and reproducible bioassay for thymosin, and is well correlated with an in vivo graft-versus-host assay. In addition, incubation of spleen cells from adult thymectomized mice with thymosin in vitro restores to normal their diminished sensitivity to azathioprine and anti-lymphocte serum.

Keywords: cell-mediated immunity, B-cells, azathioprene, thymectomy, anti-lymphocyte serum, anti-theta serum

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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