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. 1971 Dec;68(12):2958–2961. doi: 10.1073/pnas.68.12.2958

Transformation of Hamster Cells In Vitro by Polycyclic Hydrocarbons without Cytotoxicity

J A Dipaolo 1, P J Donovan 1, R L Nelson 1
PMCID: PMC389569  PMID: 5289241

Abstract

Treatment with either a flavone or benz(α)anthracene before the addition of a potent carcinogen, benzo(α)pyrene or 3-methylcholanthrene, enhanced the transformation of Syrian hamster cells that are seeded in order to form colonies. 7,8-benzoflavone and benz(α)anthracene prevented the cytotoxicity by the carcinogens, while 5,6-benzoflavone did not. The results clearly indicate that it is possible to dissociate the transforming from the toxic metabolic properties of benzo(α)pyrene and 3-methylcholanthrene.

Keywords: cloning efficiency, carcinogen, protective agents, frequency of transformation

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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