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. 1971 Dec;68(12):3045–3048. doi: 10.1073/pnas.68.12.3045

Immunoglobulin G and Free Kappa-Chain Synthesis in Different Clones of a Hybrid Cell Line

Behzad Mohit 1,*
PMCID: PMC389587  PMID: 5002282

Abstract

13 clonal cell lines were isolated from a hybrid cell population established by cell fusion between cloned BALB/c myeloma cells that were resistant to 8-azaguanine and produced immunoglobulin G and free kappa chain and C67BL/6n lymphoma cells that were resistant to bromodeoxyuridine and did not produce immunoglobulins. Some of the histocompatibility-2 antigens of both parental cell lines could be demonstrated on all of the hybrid clones. 11 clones synthesized only free kappa chain. Two clones synthesized IgG of BALB/c type, as well as free kappa chain. These clones had higher chromosome number than did the clones that synthesized only kappa chains.

Keywords: BALB, c myeloma cells, C[unk] BL, 6n lymphoma cells, azaguanine-resistant, bromodeoxyuridine-resistant

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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