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. 1971 Dec;68(12):3219–3222. doi: 10.1073/pnas.68.12.3219

Synaptogenesis in Reaggregating Brain Cell Culture

Nicholas W Seeds *, Albert E Vatter †
PMCID: PMC389625  PMID: 5289257

Abstract

Dissociated cells from embryonic mouse brain reassociate in rotation culture to form highly organized aggregates. Electron microscopic observations of aggregates show the presence of synapses that mature and increase in number during culture. Apparent myelination of axons is observed in the aggregates after 5 weeks of culture. Thus, brain cell aggregates perform two highly specialized morphological events that are characteristic of mouse brain differentiation.

Keywords: embryonic mouse, electron microscopy, axons, synapses, myelin

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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