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. 1972 Oct;69(10):2914–2917. doi: 10.1073/pnas.69.10.2914

Dog Homologue of Human β2-Microglobulin

O Smithies *, M D Poulik †,‡
PMCID: PMC389673  PMID: 4507614

Abstract

The amino-acid sequence of human β2-microglobulin, a protein of 100 residues, is related to parts of the constant region of IgG heavy chain. The dog homologue of human β2-microglobulin has now been isolated and its amino-acid sequence has been partially determined. The two proteins (human and dog β2-microglobulins) are demonstrably different at only 6 or 7 of the 42 positions examined. Use of the dog should permit experimental investigation of the functional relationships of β2-microglobulin to immunoglobulins and the immune system. β2-Microglobulin has also been detected in serum from a chimpanzee. The gene for β2-microglobulin may correspond to the end portion of an immunoglobulin heavy chain gene.

Keywords: partial amino-acid sequence, immunoglobulin heavy chain, genetic origin, immunologic significance

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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