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. 1972 Oct;69(10):2995–2999. doi: 10.1073/pnas.69.10.2995

Alteration of the Cytotoxic Action of Sensitized Lymphocytes by Cholinergic Agents and Activators of Adenylate Cyclase

Terry B Strom *, Albert Deisseroth *, Joel Morganroth *, Charles B Carpenter *, John P Merrill *
PMCID: PMC389693  PMID: 4342971

Abstract

The cytotoxic action of lymphocytes upon cells bearing alloantigens to which they are sensitized is inhibited by agents that elevate intracellular amounts of 3′:5′-cyclic AMP: prostaglandin E1, cholera toxin, and theophylline. Cholinergic agents, added in the range of 1 to 100 pM, enhance cytotoxicity, an effect that is blocked by atropine. Because cholinergic agents elevate cyclic GMP in other in vitro systems, these findings suggest that the cytotoxic process effected by sensitized lymphocytes is a secretory phenomenon modulated by cyclic AMP and cyclic GMP.

Keywords: cyclic AMP, cyclic GMP, prostaglandin E1, cholera toxin, theophylline

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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