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. 1972 Nov;69(11):3119–3123. doi: 10.1073/pnas.69.11.3119

Mammalian Cells with Altered Forms of RNA Polymerase II

V L Chan *, G F Whitmore *, Louis Siminovitch *
PMCID: PMC389717  PMID: 4508306

Abstract

Mutants of Chinese hamster ovary cells that are resistant to α-amanitin can be isolated. At least some of these mutants contain an altered form of DNA-dependent RNA polymerase II, as indicated by its resistance to α-amanitin. These results indicate that mutation to α-amanitin resistance involves a change of a structural gene.

Keywords: Chinese hamster ovary, α-amanitin

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Selected References

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