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. 1972 Nov;69(11):3128–3132. doi: 10.1073/pnas.69.11.3128

Carcinogens as Frameshift Mutagens: Metabolites and Derivatives of 2-Acetylaminofluorene and Other Aromatic Amine Carcinogens

Bruce N Ames *, E G Gurney *, James A Miller †, H Bartsch †
PMCID: PMC389719  PMID: 4564203

Abstract

Several carcinogenic metabolites of the carcinogen 2-acetyl-aminofluorene, especially 2-nitrosofluorene and N-hydroxy-2-aminofluorene, are potent frameshift mutagens for Salmonella typhimurium. 2-Nitrosonaphthalene, 2-nitrosophenanthrene, 4-nitroso-trans-stilbene, 4-nitrosobiphenyl, and 4-nitrosoazobenzene, all of which are metabolites or likely metabolites of carcinogenic aromatic amines, are also potent frameshift mutagens. These compounds may be frameshift mutagens of the class that intercalates into DNA and then reacts covalently with the DNA; various ultimate carcinogens may be of this type. The utility of a set of bacterial strains for detecting carcinogens as mutagens is shown.

Keywords: aromatic nitroso carcinogens, carcinogen detection with Salmonella, DNA intercalation

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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