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. 1972 Nov;69(11):3228–3232. doi: 10.1073/pnas.69.11.3228

Stimulated Normal Human Lymphocytes Contain a Ribonuclease-Sensitive DNA Polymerase Distinct from Viral RNA-Directed DNA Polymerase

Samuel N Bobrow *,†, R Graham Smith *, Marvin S Reitz ‡, Robert C Gallo *,§
PMCID: PMC389742  PMID: 4117771

Abstract

Ribonuclease-sensitive DNA synthesis is demonstrated in a cytoplasmic particulate fraction of normal human blood lymphocytes stimulated with phytohemagglutinin, but not in unstimulated lymphocytes. DNA polymerase purified from this fraction does not transcribe the heteropolymeric regions of 70S RNA from RNA tumor viruses, thus distinguishing this enzyme from the RNA-directed DNA polymerase (reverse transcriptase) found in oncogenic RNA viruses and human leukemic cells.

Keywords: 70S RNA, RNA tumor viruses, templates, primers

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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