Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1972 Nov;69(11):3322–3326. doi: 10.1073/pnas.69.11.3322

Nuclear Magnetic Resonance Spectrum of Deamino-Lysine-Vasopressin in Aqueous Solution and Its Structural Implications

P H Von Dreele 1, H A Scheraga 1,*, D F Dyckes 1, M F Ferger 1, V Du Vigneaud 1
PMCID: PMC389763  PMID: 4508326

Abstract

The peaks in the proton nuclear magnetic resonance spectrum of deamino-lysine-vasopressin in aqueous solution at pH values between 3 and 5 were assigned to particular amino-acid residues by use of the results of transfer-of-saturation studies, NH-CαH and CαH-CβH decoupling experiments, and other data. The conformation of deamino-lysine-vasopressin in water differs from that of lysine-vasopressin in the same solvent.

Full text

PDF
3322

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bystrov V. F., Portnova S. L., Tsetlin V. I., Ivanov V. T., Ovchinnikov Y. A. Conformational studies of peptide systems. The rotational states of the NH--CH fragment of alanine dipeptides by nuclear magnetic resonance. Tetrahedron. 1969 Feb;25(3):493–515. doi: 10.1016/s0040-4020(01)83261-0. [DOI] [PubMed] [Google Scholar]
  2. Deslauriers R., Smith I. C. Evidence from proton magnetic resonance data for the stacking of aromatic amino acids in lysine-vasopressin: comparison with oxytocin derivatives and related dipeptides. Biochem Biophys Res Commun. 1970 Jul 13;40(1):179–185. doi: 10.1016/0006-291x(70)91063-6. [DOI] [PubMed] [Google Scholar]
  3. Feeney J., Roberts G. C., Rockey J. H., Burgen A. S. Conformational studies of oxytocin and lysine vasopressin in aqueous solution using high resolution NMR spectroscopy. Nat New Biol. 1971 Jul 28;232(30):108–110. doi: 10.1038/newbio232108a0. [DOI] [PubMed] [Google Scholar]
  4. KIMBROUGH R. D., Jr, CASH W. D., BRANDA L. A., CHAN W. Y., DU VIGNEAUD V. Synthesis and biological properties of 1-desamino-8-lysine-vasopressin. J Biol Chem. 1963 Apr;238:1411–1414. [PubMed] [Google Scholar]
  5. McDonald C. C., Phillips W. D. Proton magnetic resonance spectra of proteins in random-coil configurations. J Am Chem Soc. 1969 Mar 12;91(6):1513–1521. doi: 10.1021/ja01034a039. [DOI] [PubMed] [Google Scholar]
  6. Von Dreele P. H., Brewster A. I., Bovey F. A., Scheraga H. A., Ferger M. F., Du Vigneaud V. Nuclear magnetic resonance studies of lysine-vasopressin: structural constraints. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3088–3091. doi: 10.1073/pnas.68.12.3088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Von Dreele P. H., Brewster A. I., Dadok J., Scheraga H. A., Bovey F. A., Ferger M. F., Du Vigneaud V. Nuclear magnetic resonance spectrum of lysine-vasopressin in aqueous solution and its structural implictions. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2169–2173. doi: 10.1073/pnas.69.8.2169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Von Dreele P. H., Brewster A. I., Scheraga H. A., Ferger M. F., Du Vigneaud V. Nuclear magnetic resonance spectrum of lysine-vasopressin and its structural implications. Proc Natl Acad Sci U S A. 1971 May;68(5):1028–1031. doi: 10.1073/pnas.68.5.1028. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES