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. 1972 Nov;69(11):3453–3458. doi: 10.1073/pnas.69.11.3453

Radioresistance of Carrier-Specific Helper Thymus-Derived Lymphocytes in Mice

Toshiyuki Hamaoka 1, David H Katz 1, Baruj Benacerraf 1
PMCID: PMC389792  PMID: 4539013

Abstract

The effect of x-irradiation on the capacity of carrier-specific mouse T (thymus-derived) lymphocytes to exert a helper function for hapten-specific B (bone marrow-derived) lymphocytes in vivo has been investigated again. Helper function is abolished by exposure of such cells to x-irradiation before, or immediately after, transfer to adoptive hosts. On the other hand, when exposure to x-irradiation occurs under circumstances in which the carrier-primed cells are well-localized in the appropriate lymphoid organs, i.e., either in the carrier-primed animal or 24 hr after adoptive transfer to syngeneic recipients, the capacity of T lymphocytes to serve as specific helper cells is clearly radioresistant. Evidence indicates that x-irradiation results in undefined, and subtle, changes in the migratory capacity of mouse T lymphocytes, but not in abrogation of T-cell helper function.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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