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. 1972 Dec;69(12):3516–3519. doi: 10.1073/pnas.69.12.3516

Control of the Synthesis of Fatty-Acid Synthetase in Rat Liver by Insulin, Glucagon, and Adenosine 3′:5′ Cyclic Monophosphate

M R Lakshmanan 1,2, Carl M Nepokroeff 1,2, John W Porter 1,2
PMCID: PMC389810  PMID: 4345502

Abstract

The usual increase in the activity of liver fatty-acid synthetase that occurs on refeeding of a fat-free diet to previously fasted rats is abolished in diabetic animals. Insulin specifically restores this increase by enhancement of the rate of synthesis of fatty-acid synthetase. However, glucagon and cyclic AMP inhibit the increase in the activity of fatty-acid synthetase. Therefore, the concentration of fatty-acid synthetase in rat liver is under the control of the relative concentrations of insulin and glucagon.

Keywords: fat-free diet, diabetes

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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